A short script to delete .Net temp files:
@ECHO OFF
iisreset /stop
Echo Deleting x86 Temporary ASP.NET Files
for /d %%i in ("%systemroot%\Microsoft.Net\Framework\v*") do for /d %%f in ("%%i\Temporary ASP.NET Files\*") do RD /q/s "%%f"
Echo Deleting x64 Temporary ASP.NET Files
for /d %%i in ("%systemroot%\Microsoft.Net\Framework64\v*") do for /d %%f in ("%%i\Temporary ASP.NET Files\*") do RD /q/s "%%f"
iisreset /start